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himalaya-2011-apa-sherpa-goes-for-number-21-L-z48g0PThis new and improved Optygen formula (available July 23, 2013) now contains Rhodiola that’s 40% stonger than the original formula. Why is this significant and such big news? Rhodiola Rosea continues to be one of the most published ingredients in academic literature. Every year more and more studies confirm Rhodiola modulates cortisol, improves endurance performance and improves work capacity.

  • Now with 40% Stronger Rhodiola
  • Increases Endurance and Performance
  • Modulates Cortisol Levels
  • Improves Oxygen Utilization
  • Improves work Capacity

This critically acclaimed formula is based on human clinical trials and the latest scientific research on increasing endurance. The two main adaptogens in Optygen were first used by Tibetan Sherpas to help them climb Mount Everest. Optygen utilizes these unique adaptogens because clinical research (on elite endurance athletes) has shown them to increase oxygen utilization, increase the body’s ability to adapt to high levels of physical stress, increase anaerobic threshold and reduce lactic acid.

Dr. Jeff Rocco defined the importance of modulating cortisol, in Cortisol and Overtraining Syndrome: Why and Athlete Should Care He states “Chronically elevated levels of cortisol have a number of undesirable effects for athletes. Elevated cortisol levels lead to a perpetual catabolic state where muscle is broken down, and fat is stored. Decreased levels of testosterone in men, and decreased levels of progesterone and estrogen in women may further impair recovery. While these hormones are usually thought of as sex hormones, they are also anabolic and potentiate recovery. Chronic stress causes both an increase in cortisol and a decrease in testosterone, estrogen, and progesterone. This can lead to amenorrhea in women, and stress fractures in both men and women. Chronically elevated cortisol levels, which are associated with overtraining, lead to suppressed immune system function and reduced exercise capacity. Sick, injured and slow is no way to conduct your season.”

The following studies help further validate the importance of Rhodiola and its effect on your stress.


Panossian A, Wikman G.

Clinical Pharmacology. 2009 Sep;4(3):198-219. Epub 2009 Sep 1.

Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.

This 2009 study assessed the level of scientific evidence that supports using the adaptogen Rhodiola to reduce fatigue. The review concluded that this phytoadaptogen up-regulates the stress-mimetic effects on the “stress-sensor” protein Hsp70. Hsp70 interacts with glucocorticoid receptors, which affect the levels of circulating cortisol. The study concluded rhodiola prevents stress-induced increase in NO, results in increased performance and endurance. Adaptogen induced up-regulation of Hsp70 regulates the resistance to stress and results in enhanced mental and physical performance and, possibly, increased longevity.

Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ.

Journal of Strength and Conditioning. 2012 May 24. [Epub ahead of print]

The Effects of an Acute Dose of Rhodiola Rosea on Endurance Exercise Performance.

The purpose if this 2012 study was to determine the effects of an acute oral dose of 3mg/kg Rhodiola Rosea on endurance exercise performance, perceived exertion, mood and cognitive function. Subjects warmed up for 10 minutes then did a 6-mile TT on a bicycle ergometer. The Rhodiola group showed a significantly lower HR during warm up, significantly faster TT and a significantly lower rate of perceived exertion. The study concluded that an acute dose of Rhodiola Rosea ingestion decreased heart rate response to sub-maximal exercise and appears to improve endurance exercise performance by decreasing the perception of effort.

Parisi A, Tranchita E, Duranti G, Ciminelli E, Quaranta F, Ceci R, Cerulli C, Borrione P, Sabatini S.

Journal of Sports Medicine and Physical Fitness. 2010 Mar;50(1):57-63.

Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results.

The purpose of this study was to investigate the effects of Rhodiola Rosea on physical performance and on the redox status of chronic Rhodiola Rosea supplementation in a group of competitive athletes during endurance exercise. Following a 4-week Rhodiola Rosea supplementation protocol, athletes underwent a cardio-pulmonary exhaustion test. The study found athletes had significantly lower blood lactate levels and plasma creatine kinase levels (this is a marker of protein regulation and overtraining). The study concluded that Rhodiola supplementation is able to reduce both lactate levels and parameters of skeletal muscle damage following an exhaustive exercise session.

In addition, these two separate trials done were done on the Optygen formula:

In a 2007 clinical trial on endurance trained athletes Dr. Andrew Creer of South Dakota State University showed Optygen to reduce cortisol (the primary stress hormone) by 26%. Cortisol is a catabolic (breakdown) hormone that the body produces when under stress, such as after hours of running. Chronically elevated cortisol levels can prevent an athlete from recovering, increase the risks of overtraining and suppress the immune system. Researchers concluded that Optygen is beneficial for trained athletes undergoing high training volumes because it decreases baseline stress and improves training sessions.

Another study done by Dr. Karlton Larson (2007 Luther College) showed endurance athletes who used Optygen increased the time to lactate threshold by 42%. Results of this study show Optygen is effective in reducing lactic acid production and delaying onset of lactate threshold (the exercise intensity at which lactic acid starts to accumulate in the blood stream), therefore improving endurance.