Clinically Proven to Increase Endurance & Performance

Optygen is a legal, safe and stimulant-free formula that designed specifically to improve oxygen utilization, reduce lactic acid and allow the body to adapt to high levels of physical stress.

✓ Increases VO2 Max
✓ Improves Oxygen Utilization & Anaerobic Threshold
✓ Modulates Cortisol & Reduces Lactic Acid

Overall Average Rating:
2 reviews

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Zac 299/10/2014 27/10/201419:52
  • Overall:
Road and Mountain Cyclist
I have been using Optygen for the past two seasons. During this time, I have seen my best results and seen my PR's continue to improve. This stuff is like magic. I use it with the MultiV.
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Thomas TeamR2W 181/07/2014 01/07/201414:51
  • Overall:
Great product!
I have been using Optygen for about a month. It took approximately one week to notice a difference in my training (the loading phase). Sadly I was dealing with an injury during the beginning of this month and was cross training more than running but I think that really made me notice the difference even more. I was doing a lot of riding on a stationary bike and noticed improvements in my RPMs and how me effort felt at certain rates and resistance levels.
Training for a half marathon right now and look forward to seeing the effects during some 100 mile training weeks.
Side note: I was worried when I tried about any side effects and also about any lingering bad taste (I hate when you burp after taking something like this and it tastes horrible) this was not an issue. I have seen no adverse side effects and no bad after taste! I think I will upgrade to OptygenHP and see what that is like.
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    This critically acclaimed formula is based on human clinical trials and the latest scientific research on increasing endurance. The two main adaptogens in Optygen were first used by Tibetan Sherpas to help them climb Mount Everest. Optygen utilizes these unique adaptogens because clinical research on elite endurance athletes has shown them to increase oxygen utilization, increase the body’s ability to adapt to high levels of physical stress, increase anaerobic threshold and reduce lactic acid. 


    A study done by South Dakota State University showed Optygen reduces cortisol levels (the primary stress hormone) by 26%. Chronically elevated cortisol levels can prevent an athlete from recovering, increase the risks of overtraining and suppress the immune system. 


    A 2012 study done at Luther College showed endurance athletes who used Optygen increased time to lactate threshold by 42%. The purpose of this study was to determine the effects on highly trained distance runners of Optygen.

    Though changes in performance variables (VO2 max, hemoglobin, serum ferritin and salivary cortisol) were similar between groups, time to onset of lactate threshold was nearly 42% greater in E=experimental vs C=control group.



    Optygen works on three different levels all working synergistically with the goal of increasing endurance. Endurance is defined as your ability to perform work over a period of time where there is oxygen delivered to the muscles. There are three critical components necessary to increase your endurance capacity.

    1. Efficient Oxygen Transfer

    Rhodiola and Cordyceps are the key ingredients in Optygen. Clinical research on elite athletes has shown both these adaptogenic herbs increase oxygen utilization, increase the body’s ability to adapt to high levels of physical stress, increase anaerobic threshold and reduce lactic acid. These herbs are both found and cultivated in Tibet. Clinical studies on Cordyceps have shown it increases endurance. In a 1998 study, Dr. Edmond Burke demonstrated how these two adaptogenic herbs improve the efficiency of oxygen transfer in the cell leading to improvements in oxygen uptake and VO2max.

    2. ATP Production

    Endurance athlete’s VO2max is directly proportional to their ability to efficiently produce Adenosine Triphosphate (ATP). Clinical research has shown that endurance athletes diminish their ATP stores in exhaustive exercise, which can lead to a reduction in aerobic metabolism and endurance. Since ATP is the final step in aerobic energy production, it’s critical that the nutrients feeding the ATP cycle are readily available. Calcium pyruvate, sodium phosphate, potassium phosphate, adenosine and d-ribose all play critical roles in glycolysis and the citric acid cycle, leading to efficient ATP production. Optygen’s proprietary ATPro™ matrix of five key nutrients is designed to assure ATP production.

    3. Efficient Glucose Metabolism

    The Optygen formula utilizes chromium for its ability to break down fuel. Chromium is an essential trace mineral that aids in glucose metabolism, regulation of insulin levels, and maintenance of healthy blood levels of cholesterol and other lipids. Chromium forms part of a compound in the body known as Glucose Tolerance Factor (GTF), which is involved in regulating the actions of insulin in maintaining blood sugar levels and, possibly, in helping to control appetite. It’s critical that any drink, bar or meal consumed prior to a race or exercise gets broken down efficiently in order to maximize your fuel delivery. Insulin spikes or lack of insulin response can cause the nutrients to either be rushed into your bloodstream too quickly or not quickly enough. Chromium regulates this nutrient breakdown so you have equal and sustained nutrient delivery to the working muscles.


    Q: How long will it take before I start noticing the benefits?

    A: You should start experiencing the benefits of OPTYGEN approximately six (6) days after you start taking OPTYGEN.

    Q: When should I take OPTYGEN?

    A: It is best to take Optygen in the morning with a meal.

    Q: How long will a bottle last?

    A: OPTYGEN has a 7-day loading phase. Because of this, the first bottle will last 23 days. After the loading phase has been done, each bottle is a 30-day supply.

    Q: Will OPTYGEN help me recover faster?

    A: Yes, it will help you recover. Because OPTYGEN will help you adapt during times of maximum stress, it also aids in recovery.

    Q: Why are the capsules red?

    A: capsules are dark red, not clear, to further reduce UV light degradation ensuring the highest quality, potency, and purity.

    Q: What’s the difference between Optygen and OptygenHP?

    A: Great question! The link below details the differences between Optygen and OptygenHP:

    Q: Why is the bottle glass instead of plastic?

    A: OPTYGEN is packaged in an amber glass bottle. Unlike plastic bottles, amber glass is an impermeable barrier that protects the product from harmful UV light and oxygen degradation.

    Q: Why does OPTYGEN have Cordyceps and Rhodiola Rosea?

    A: OPTYGEN utilizes two adaptogens that are the primary ingredients in the formulation. Patented Rhodiola Rosea and Cordyceps are both found and cultivated in Tibet. Both these herbs play critical roles in allowing the body to adapt to high levels of physical stress (similar to the stress a body is subject to when climbing Everest). It’s these adaptations to hypoxia (lack of oxygen) which led researchers to also test its effects on elite endurance athletes. Both Rhodiola and Cordyceps have been clinically shown to increase VO2Max, lung function, oxygen utilization and anaerobic threshold significantly.

    Q: How should I use Optygen?

    A: For best results, use Optygen during all intense training. Optygen will allow you to train at a higher level by improving the body’s ability to adapt to physical stress, increasing aerobic threshold and reducing lactic acid. These improvements will help you race at a higher level. For best results, Optygen should be used consistently for many months. If you start taking Optygen a week before a race, benefits will be minimal.



    First Endurance offers everything an endurance athlete needs to maximize endurance and performance.  We designed it to work as a complete endurance system. Each product has a specific purpose and complements the others.

    With First Endurance, there’s no more guesswork.