$79.95 USD


OptygenHP is engineered to help increase endurance and performance with the highest-grade adaptogens available. Each serving of OptygenHP also delivers 1500mg of Beta-Alanine to boost power and enhance exercise capacity.

✓Increases Time to Exhaustion & VO2 Max
✓Improves ATP Energy Production
✓Boosts Power and Exercise Capacity


The adaptogens Rhodiola, Ashwagandha and Cordyceps are ideal for elite athletes. Their benefits include increased time to exhaustion, reduced fatigue, less impact from lactic acid and overtraining, expanded anaerobic capacity, improved VO2 max, and more efficient energy production. In short, adaptogens improve endurance performance.



If you’re not satisfied, we don’t expect you to pay. Return it within 30 days for a refund or credit. It’s that simple.

"I’ve used First Endurance for the majority of my career and it’s been part of many of my career highlights and the preparation to get there!"
Ben King

2x stages La Vuelta ciclista a España


A study done by South Dakota State University showed OptygenHP reduces cortisol levels (the primary stress hormone) by 26%. Chronically elevated cortisol levels can prevent an athlete from recovering, increase the risks of overtraining and suppress the immune system. 

"OptygenHP is a supplement unlike any other and one I have used in every Grand Tour I‘ve raced, and every year since I was 15! To have a supplement that helps you adapt to the stress of huge training and race loads is a big help. I’m happy to have it in my arsenal!”

– Larry Warbasse (AG2R Citroën Professional Cycling Team)


A study done at Luther College showed endurance athletes who used Optygen increased time to lactate threshold by 42%. The purpose of this study was to determine the effects on highly trained distance runners of OptygenHP.

Though changes in performance variables (VO2 max, hemoglobin, serum ferritin and salivary cortisol) were similar between groups, time to onset of lactate threshold was nearly 42% greater in E=experimental vs C=control group.



The OptygenHP formula utilizes chromium for its ability to break down fuel. Chromium is an essential trace mineral that aids in glucose metabolism, regulation of insulin levels, and maintenance of healthy blood levels of cholesterol and other lipids. Chromium forms part of a compound in the body known as glucose tolerance factor (GTF), which is involved in regulating the actions of insulin in maintaining blood sugar levels and, possibly, in helping to control appetite. It is critical that any drink, bar or pre-race meal consumed prior to a race or exercise gets broken down efficiently in order to maximize fuel delivery.  Insulin spikes or lack of insulin response can cause the nutrients to either be rushed into the bloodstream too quickly or not quickly enough.  Chromium regulates this nutrient breakdown so equal and sustained nutrients are delivered to the working muscles. The most widely available sources are chromium salts such as chromium polynicotinate and chromium picolinate. OptygenHP uses chromium chelate, a unique form of chromium patented for its superior absorption and bioavailability properties.


OptygenHP utilizes Beta-alanine to efficiently synthesize lactate to be re-used as fuel. Beta-alanine is a non-essential beta-amino acid. L-carnosine enters the digestive system and is hydrolyzed into histidine and beta-alanine, which is then synthesized back into carnosine by skeletal muscle. It is with intense training that athletes improve their muscle carnosine content by up to 87% (Harris, 2005). With intense training, carnosine levels can be increased, but with a limiting factor: the body cannot produce enough beta-alanine to allow the body to continue to increase carnosine levels. Clinical studies show that supplementing with beta-alanine allows the body to produce significantly higher carnosine levels. Through its effect on carnosine levels, beta-alanine synthesizes lactic acid to be re-used as fuel.  The result is a highly effective mechanism for the metabolism of lactate, which in turn improves endurance capacity allowing training and racing at a higher level.


OptygenHP contains adaptogenic herbs to improve oxygen efficiency.  This next-generation formula has been upgraded with Ashwagandha to enhance VO2 Max more than ever before.

Originally, these adaptogenic herbs were gathered by Tibetan Sherpas for use in their tea. The Sherpas used these herbs to give them energy to climb Everest, which they did without the use of supplemental oxygen. One of the adaptogenic applications of Rhodiola that has received considerable research attention recently is in adaptation to high altitude – a preventive treatment for hypoxia, or mountain sickness. In June 2002, Dr. Rulin Xiu was awarded a patent for her work showing Rhodiola’s ability to oxygenate blood. Clinical studies on Cordyceps have proven its ability to increase endurance through more efficient enzyme activity, mobilization of free fatty acids and beta-oxidation. In a 1998 study, Dr. Edmond Burke observed that Cordyceps has the ability to improve lactate energy metabolism within the cell. All these mechanisms clearly show how these two adaptogenic herbs improve the efficiency of oxygen transfer in the cell leading to improvements in oxygen uptake and VO2max.


OptygenHP increases efficient Adenosine Triphosphate (ATP) production. Clinical research has shown that endurance athletes diminish their ATP stores in exhaustive exercise, which can lead to a reduction in aerobic metabolism and endurance. OptygenHP’s proprietary ATPro™ matrix of five key nutrients is designed to ensure ATP production.  Since ATP is the final step in aerobic energy production, it is critical that the nutrients feeding the ATP cycle are readily available. Calcium pyruvate, sodium phosphate, potassium phosphate, adenosine and d-ribose all play critical roles in glycolysis and the citric acid cycle, leading to efficient ATP production. An endurance athlete’s VO2max is directly proportional to the body’s ability to efficiently produce ATP.


Dosage recommendations: Take 4 capsules daily with a meal.

For best results, use OptygenHP during all intense training. OptygenHP should be used consistently for many months. If you start taking OptygenHP a week before a race, benefits will be minimal.

Supplement Facts
Serving Size: 4 Capsules
Amount Per Serving %DV
Calcium (as Calcium pyruvate) 8%
Chromium (as chromium nicotinate glycine chelate))** 200 mcg 167%
Ashwagandha Extract (Withania Somnifera)(root) 150 mg *
Rhodiola Extract (Rhodiola Rosea)(root) 5% rosavins 150 mg *
Cordyceps (from Cs-4 Paecilomyces hepiali and Cordyceps militaris extracts) (mycelia biomass) 800 mg *
Beta-Alanine 1500mg *
Senactiv® Proprietary matrix (Panax notoginseng extract, Rosa roxburghii fruit extract)*** 50mg *
ATProTM Matrix (Calcium Pyruvate, Sodium Phosphate, Potassium Phosphate, Ribose) 500mg *

*Daily Value Not Established

Other Ingredients: Gelatin capsule. Contains: Soy

** Covered by Albion international, Inc., U.S. Patent 5,614,553.

***Senactiv® is a registered trademark of Nuliv Science USA, Inc.


Q: How is this OptygenHP formula different than the previous formula?

A: This formula contains the adaptogenic herb ashwagandha.  Research shows ashwaganda improves VO2max, modulates cortisol and increases work output.    We have substituted 150mg of Rhodiola with 150mg of ashwagandha. The formula delivers 150mg Rhodiola, 150mg ashwagandha, 800mg cordyceps, 200mcg chromium, 50mg ActiGin and our proprietary ATPro matrix.

Q: Why are the capsules red?

A: The capsules are dark red to further reduce UV light degradation ensuring the highest quality, potency, and purity.

Q:  How will OptygenHP help me race better?

A:  This formula will dramatically improve your training and recovery.  It’s designed to help you through your most intense training and racing. Research has shown the following endurance benefits:

Increases Endurance and PerformanceReduced Lactic Acid

Increases oxygen utilization

Increase in VO2 Max

Increase in Time to Exhaustion

Increase Anaerobic threshold

Improved exercise capacity

Increase Maximal Oxygen uptake

30% – 50% increase in Oxygen Utilization

Increase ratio of ATP by 45% – 55%

Enhanced Endurance

Increase in ATP production

Q: How do I maximize the benefits?

A:  For best results, use OptygenHP during all your intense training and racing. This will allow you to train at a higher level by improving the body’s ability to adapt to physical stress, increasing anaerobic threshold and reducing lactic acid. These improvements will help you race at a higher level. For best results, you should use OptygenHP consistently for many months. If you start taking it a week before a race, benefits will be minimal. 

Q: Should I take OptygenHP every day?

A: Yes, it’s important to take OptygenHP daily, even on days you are not training or racing.  If you don’t take it every day, you will not experience the full potential.

Q: How long will it take before I start noticing the benefits?

A: You should start experiencing the benefits of OptygenHP formula approximately six (6) days after you start taking it.

Q: When should I take OptygenHP?

A: It is best to take OptygenHP formula every day with a meal.

Q: What is Beta-Alanine and how does it work?

A: Beta-Alanine is an amino acid that interacts directly with the amino acid carnosine to buffer lactic acid. With intense training, you can increase your carnosine levels with a limiting factor: the body cannot produce enough Beta-Alanine to allow the body to continue to increase carnosine levels. Clinical studies show that supplementing with Beta-Alanine allows the body to produce significantly higher carnosine levels. The result is a highly effective mechanism for the metabolism of lactate, which in-turn improves endurance capacity.

Q: Can I give my son and daughter Optygen or OptygenHP?

A:  Because there haven't been any published clinical studies on people under 18, we do not recommend Optygen or OptygenHP to athletes who are under 18 years of age.  

Q: What are the benefits of taking Beta-Alanine?

A: Cutting edge human clinical studies show Beta-Alanine supplementation:

Significantly improves muscular endurance.Improves exercise capacityIncreases Total Work Done by 13%Boosts strength
Increases endurance capacityEnhances Ventilatory ThresholdDelays onset of neuromuscular fatigue

Q:  Is the OptygenHP formula legal?

A: Absolutely.  First Endurance has taken additional measures to ensure that our products are safe, legal and stimulant free.  First Endurance supplements are legal to use in any sporting event governed by the World Anti-Doping Association (WADA), the US anti-doping association (USADA) and by the UCI (Union Cycliste International), US Cycling, International Cycling, US Triathlon and International Triathlon.  

Some commonalties among these governing bodies include banned substances which fall into one or more of the following categories as listed in Section I A-E of the UCI Prohibited Classes of substance and Prohibited Methods document.  A) Stimulants B) Narcotics C) Anabolic agents D) Diuretics and E) Peptide hormones, mimetics and analogues. This document goes on to list banned substances within each of these classes. Regulations also ban ‘Compounds chemically or pharmacologically related to the products mentioned’.  

OptygenHP contains NO ingredients, which are explicitly listed under the banned substance list, nor are any of the ingredients related chemically or pharmacologically.  First Endurance has also contacted the USADA and received verbal confirmation that our ingredients are not banned based on their regulations. Note: USADA, WADA and UCI do not offer any certification or written confirmation.  

First Endurance manufactures its formulations to the highest GMP (Good Manufacturing Practice) standards available.  In addition we use a proprietary manufacturing method for added safety and assurance. Following the Supplement Facts panel you will notice we list ‘NO processing aids’ under Other Ingredients.   The only ingredients found in this formulation, are those listed in the Supplement Facts Panel.

Part XIV Article 7 of the Anti-doping Examination Regulations contains the following warning: riders must refrain from using any substance, foodstuff or drink of which they do not know the composition.  It must be emphasized that the composition indicated on a product is not always complete. The product may contain prohibited substances not listed in the composition.

Q: Will OptygenHP help me recover faster?

A: Yes, it will help you recover.  Because this formula was developed to help you adapt during times of maximum stress, it also aids in recovery.

Q: Should I ‘cycle’ on and off with Optygen/OptygenHP?

A: Great question. Both these products work best when you are ‘stressed’, so use the product during stressful training. The cycling period should parallel your training program. In other words, you should be using Optygen/OptygenHP consistently through all hard training blocks/months and go off anytime you have a break or downtime. For some, this means being on the product through most if not all the racing season. For others, it might mean cycling off for a week once every 4-6 weeks.