$79.95 USD


OptygenHP is a legal, safe and stimulant-free formula that’s engineered to increase endurance capacity.  Studies on endurance athletes who used OptygenHP had a 42% increase in time to lactate threshold, a 26% reduction in cortisol (the primary stress hormone) and a significant improvement in endurance capacity.

✓ Maximizes oxygen utilization & VO2 max
✓ Optimizes ATP production
✓ Reduces & buffers lactic acid

Customer reviews

Breakthrough Year!

“I immediately saw the difference in training. My heart rate dropped significantly and I was able to push harder at a lower heart rate.”
— Daniel

Big Gains Fast

“I increased my Vo2 Max by 5 points in the first 10 weeks!
— Mark

Game Changer

“Quite literally a game changer for endurance athletes looking to optimize their performance gains.”
— Shannon
Smarter training. Higher intensity. Higher ceiling.


OptygenHP’s clinically effective dose of beta-alanine enables harder training, delays fatigue, and shortens recovery periods with antioxidant effects. It also helps your body manage lactic acid, contributing to the process that buffers lactic acid into less acidic salts. Instead of entering the bloodstream as waste, the buffered lactate can be repurposed as energy by the cells that generate it. From toxic waste to fuel – a process made all the more valuable when the body is generating elevated amounts of lactic acid.

"I love that OptygenHP gives your body the extra support it needs to perform, whether in training or racing."
Whitney Allison

1st Overall BWR Cedar City (2022)
2nd Overall SBT Gravel (2022)
4th Overall Unbound Gravel (2022)


"OptygenHP is a supplement unlike any other and one I have used in every Grand Tour I‘ve raced, and every year since I was 15! To have a supplement that helps you adapt to the stress of huge training and race loads is a big help.”

– Larry Warbasse (AG2R Citroën Professional Cycling Team)

Boosts recovery and glycogen supply

Senactiv® contains Rg1 at the same dose used in human clinical trials.


Clinical studies show that the Senactiv® in OptygenHP also decreases exercise-induced muscle damage and reduces post-exercise inflammation by supporting autophagy, the process of your body clearing damaged cells and proteins in order to help recovery and drive training adaptations. More efficient recovery; faster return to form between workouts and races.



OptygenHP contains a patented ingredient, Senactiv®,  that has been scientifically validated in human studies to extend high-intensity exercise performance by up to 20% while also tripling muscle glycogen accumulation rate during the three hours following high-intensity exercise.

You’ll have more reserves for the finale and less downtime between intervals – or while responding to attacks. Find another effort in yourself, sooner, and race like the next gap will be the one that sticks.

Senactiv® contains Rg1 at the same dose used in human clinical trials.
Tested in clinical research. Proven on Everest.


OptygenHP’s expanded suite of adaptogens adds Ashwagandha to Cordyceps and Rhodiola (first used by Tibetan Sherpas to adapt to the extreme physical stress and low oxygen environments on the upper reaches of Everest). The latest clinical research on elite endurance athletes supports the Sherpas’ use of adaptogens to improve performance, with studies showing increases to VO2Max, lung function, and oxygen utilization. Adaptogens also boost anaerobic threshold and time to exhaustion, and they even mobilize free fatty acids to metabolize as fuel.

Adaptogens aren’t stimulants, meaning you may not “feel” something shortly after taking them. Instead, they acclimate your body to the mental and physical stress inherent in intense training blocks, which can negatively impact performance. The effects will be noticeable in 7-10 days, but the ultimate benefits will gradually accumulate over a period of months during long-term consistent intake. Adaptogens aren’t a shortcut; they’re a tool to help you get more out of your training, faster. How strong do you want to be, and how long are you willing to wait to get there?

Reduces the risk of overtraining


Endurance training pumps additional cortisol, the primary stress hormone, into your system, which negatively impacts motivation, sleep, and the immune system. Chronically elevated cortisol also inflicts a penalty on performance, workload, and recovery by suppressing testosterone levels and dropping the panicked body into a catabolic state, which involves metabolizing muscle while storing fat. When we say “overtraining,” this is what we mean.

A clinical study showed OptygenHP reduced post-exercise levels of cortisol by 26%. By modulating cortisol, athletes experience better recovery, an increase in VO2, improved oxygen utilization and enhanced performance. When every session is critical, OptygenHP ensures you’re getting maximum returns without the risk of overtraining.


% Change in Post Exercise Cortisol Relative to Placebo.

“Utilization of OptygenHP proves beneficial to trained athletes undergoing high training volumes by decreasing baseline stress and improving training sessions, leading to an overall improvement in performance."

- Excerpt from a pilot study conducted by Dr. Andrew Creer of South Dakota State University

Clinically shown to increase lactate threshold

Time to Lactate Threshold (Seconds)

Control 13.9 seconds vs Optygen 18.1 seconds after 7 weeks


OptygenHP’s adaptogen blend weaponizes the lactic acid that accumulates in muscles as exercise output outpaces oxygen intake and energy metabolism goes anaerobic. In a clinical study, adaptogens in the OptygenHP formula increased time to the lactate threshold by 42%, even in highly trained distance runners.

In real world terms, that’s about five additional seconds before threshold: 13.9 seconds versus 18.1. That can make all the difference during repeated attacks or when the elastic is stretching and every moment could see it snap. OptygenHP turns the lactate threshold into an opportunity for you – and an even bigger weakness for your competition.

"With OptygenHP, my capacity to handle a massive training load and then absorb and improve is noticeable."
Rob Britton

Gravel Privateer

The building blocks of ATP


OptygenHP’s proprietary ATPro™ matrix of five key nutrients plays a critical role in the processes leading to efficient production of ATP, which is the energy source that powers everything we do. Every stride, every pedal stroke, every meter gained through the water – ATP is critical for endurance athletics. Clinical research shows that endurance athletes diminish their ATP stores in exhaustive exercise, so it’s equally critical that the nutrients feeding the ATP cycle – the process of converting glucose to ATP energy – are readily available.

Improves body composition


Regulating insulin, metabolizing glucose, mobilizing fatty acids for fuel – OptygenHP’s biologically active chromium touches on virtually every aspect of getting grist to the mill of cellular energy production. It meters the delivery of calories to sustain a steady energy supply, and your body doesn’t have to pull as much fuel from your muscles – both during exercise and daily life – so you’re also building a leaner, more competition-tuned body composition, all year long.

Despite its impact on body composition, chromium isn’t a gimmicky weight loss wonder drug. It’s an essential trace mineral, and it’s supported by research that shows it helps your body more efficiently process foods to fuels – especially when combined with MultiV, which also contains chromium.

Photo: Miguel Rúa


Dosage recommendations: Take 4 capsules daily with a meal.

For best results, use OptygenHP during all intense training. OptygenHP should be used consistently for many months. If you start taking OptygenHP a week before a race, benefits will be minimal.

Supplement Facts
Serving Size: 4 Capsules
Amount Per Serving %DV
Calcium (as Calcium pyruvate) 8%
Chromium (as chromium nicotinate glycine chelate)** 200 mcg 167%
Ashwagandha Extract (Withania Somnifera)(root) 150 mg *
Rhodiola Extract (Rhodiola Rosea)(root) 5% rosavins 150 mg *
Cordyceps (from Cs-4 Paecilomyces hepiali and Cordyceps militaris extracts) (mycelia biomass) 800 mg *
Beta-Alanine 1500mg *
Senactiv® Proprietary matrix (Panax notoginseng extract, Rosa roxburghii fruit extract)*** 50mg *
ATProTM Matrix (Calcium Pyruvate, Sodium Phosphate, Potassium Phosphate, Ribose) 500mg *

*Daily Value Not Established

Other Ingredients: Gelatin capsule. Contains: Soy

** Covered by Albion international, Inc., U.S. Patent 5,614,553.

***Senactiv® is a registered trademark of Nuliv Science USA, Inc.


Q: How is this OptygenHP formula different than the previous formula?

A: This formula contains the adaptogenic herb ashwagandha.  Research shows ashwaganda improves VO2max, modulates cortisol and increases work output.    We have substituted 150mg of Rhodiola with 150mg of ashwagandha. The formula delivers 150mg Rhodiola, 150mg ashwagandha, 800mg cordyceps, 200mcg chromium, 50mg ActiGin and our proprietary ATPro matrix.

Q: Why are the capsules red?

A: The capsules are dark red to further reduce UV light degradation ensuring the highest quality, potency, and purity.

Q:  How will OptygenHP help me race better?

A:  This formula will dramatically improve your training and recovery.  It’s designed to help you through your most intense training and racing. Research has shown the following endurance benefits:

Increases Endurance and PerformanceReduced Lactic Acid

Increases oxygen utilization

Increase in VO2 Max

Increase in Time to Exhaustion

Increase Anaerobic threshold

Improved exercise capacity

Increase Maximal Oxygen uptake

30% – 50% increase in Oxygen Utilization

Increase ratio of ATP by 45% – 55%

Enhanced Endurance

Increase in ATP production

Q: How do I maximize the benefits?

A:  For best results, use OptygenHP during all your intense training and racing. This will allow you to train at a higher level by improving the body’s ability to adapt to physical stress, increasing anaerobic threshold and reducing lactic acid. These improvements will help you race at a higher level. For best results, you should use OptygenHP consistently for many months. If you start taking it a week before a race, benefits will be minimal. 

Q: Should I take OptygenHP every day?

A: Yes, it’s important to take OptygenHP daily, even on days you are not training or racing.  If you don’t take it every day, you will not experience the full potential.

Q: How long will it take before I start noticing the benefits?

A: You should start experiencing the benefits of OptygenHP formula approximately six (6) days after you start taking it.

Q: When should I take OptygenHP?

A: It is best to take OptygenHP formula every day with a meal.

Q: What is Beta-Alanine and how does it work?

A: Beta-Alanine is an amino acid that interacts directly with the amino acid carnosine to buffer lactic acid. With intense training, you can increase your carnosine levels with a limiting factor: the body cannot produce enough Beta-Alanine to allow the body to continue to increase carnosine levels. Clinical studies show that supplementing with Beta-Alanine allows the body to produce significantly higher carnosine levels. The result is a highly effective mechanism for the metabolism of lactate, which in-turn improves endurance capacity.

Q: Can I give my son and daughter Optygen or OptygenHP?

A:  Because there haven't been any published clinical studies on people under 18, we do not recommend Optygen or OptygenHP to athletes who are under 18 years of age.  

Q: What are the benefits of taking Beta-Alanine?

A: Cutting edge human clinical studies show Beta-Alanine supplementation:

Significantly improves muscular endurance.Improves exercise capacityIncreases Total Work Done by 13%Boosts strength
Increases endurance capacityEnhances Ventilatory ThresholdDelays onset of neuromuscular fatigue

Q:  Is the OptygenHP formula legal?

A: Absolutely.  First Endurance has taken additional measures to ensure that our products are safe, legal and stimulant free.  First Endurance supplements are legal to use in any sporting event governed by the World Anti-Doping Association (WADA), the US anti-doping association (USADA) and by the UCI (Union Cycliste International), US Cycling, International Cycling, US Triathlon and International Triathlon.  

Some commonalties among these governing bodies include banned substances which fall into one or more of the following categories as listed in Section I A-E of the UCI Prohibited Classes of substance and Prohibited Methods document.  A) Stimulants B) Narcotics C) Anabolic agents D) Diuretics and E) Peptide hormones, mimetics and analogues. This document goes on to list banned substances within each of these classes. Regulations also ban ‘Compounds chemically or pharmacologically related to the products mentioned’.  

OptygenHP contains NO ingredients, which are explicitly listed under the banned substance list, nor are any of the ingredients related chemically or pharmacologically.  First Endurance has also contacted the USADA and received verbal confirmation that our ingredients are not banned based on their regulations. Note: USADA, WADA and UCI do not offer any certification or written confirmation.  

First Endurance manufactures its formulations to the highest GMP (Good Manufacturing Practice) standards available.  In addition we use a proprietary manufacturing method for added safety and assurance. Following the Supplement Facts panel you will notice we list ‘NO processing aids’ under Other Ingredients.   The only ingredients found in this formulation, are those listed in the Supplement Facts Panel.

Part XIV Article 7 of the Anti-doping Examination Regulations contains the following warning: riders must refrain from using any substance, foodstuff or drink of which they do not know the composition.  It must be emphasized that the composition indicated on a product is not always complete. The product may contain prohibited substances not listed in the composition.

Q: Will OptygenHP help me recover faster?

A: Yes, it will help you recover.  Because this formula was developed to help you adapt during times of maximum stress, it also aids in recovery.

Q: Should I ‘cycle’ on and off with Optygen/OptygenHP?

A: Great question. Both these products work best when you are ‘stressed’, so use the product during stressful training. The cycling period should parallel your training program. In other words, you should be using Optygen/OptygenHP consistently through all hard training blocks/months and go off anytime you have a break or downtime. For some, this means being on the product through most if not all the racing season. For others, it might mean cycling off for a week once every 4-6 weeks.

Q: What are the ingredients of the OptygenHP capsule?

A: The OptygenHP capsule is made of Bovine Gelatin without preservatives, includes FDA-approved FD&C Red #40 and Titanium dioxide at 1.5% of capsule weight. (also FDA-approved). It's also Kosher and Halal certified.