This new and improved OptygenHP is based on the latest clinical research on adaptogenic herbs and their effect on endurance athletes.

✓ Increases VO2 Max
✓ Improves Oxygen Utilization & Anaerobic Threshold
✓ Modulates Cortisol & Reduces Lactic Acid

Overall Average Rating:
7 reviews

1-5 of 7

  1. 1
  2. 2
Jamie 187/07/2019 07/07/201922:39
  • Overall:
My only regret is waiting this long
After using OptygenHP for the past few months, my only regret is waiting so long to try it. I've had PR's on all my normal routes and I'm having the best race season of my life.
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Sarah O 176/06/2019 26/06/201917:04
  • Overall:
I feel great!
I feel amazing when taking Optygen. I'm not as stressed, I sleep better and I've got the energy I need. I take Optygen and EFS daily and Ultragen after hard days.
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Chris 172/06/2019 22/06/201919:13
  • Overall:
Give it time to kick in
I didn't notice any major difference the first week or two. The 3rd week is when I really started to see the benefits. After using it for 1 month now, I've noticed pretty significant improvements in threshold power and recover. My times on all the local climbs are faster. I've also noticed I'm able to handle back to back hard days much better than before.
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Gabriel 163/06/2019 13/06/201921:16
  • more than 7 month(s)
  • Overall:
Firm Believer
I started taking Optygen HP back in 2017 before the new 2019 version was released. I loved it then and I love it now. After trying the prototype of the 2019 formula, I noticed an even greater ability to push harder (more power, faster pace) and maintain the same HR and Lactate levels. I'm a firm believer in Optygen HP.
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Lauren 339/12/2019 06/12/201914:46
  • Overall:
Power and heart rate tell all
I've been skeptical about OptygenHP for years. I didn't believe it could really make a difference and didn't think it was worth the money. The coach I hired this year suggested I try it though, so I did. I followed the directions and used it religiously for three months.

Since then, my power output has gone up 7% and I am able to maintain my anaerobic threshold 9% longer than before. Those numbers are real.
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1-5 of 7

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    The new and improved OptygenHP has been engineered to optimize endurance and performance. This next-generation formula has been upgraded with Ashwagandha to modulate cortisol, improve power and enhance VO2 Max. In addition there are clinically effective doses of premium grade Rhodiola & Cordyceps because research shows this combination of endurance-specific adaptogens improves aerobic performance. Each serving of OptygenHP also delivers 1500mg of Beta-Alanine to boost strength and enhance exercise capacity.

    The main adaptogens in OptygenHP were first used by Tibetan Sherpas to help them climb Mt. Everest. OptygenHP contains these unique adaptogens because clinical research on elite endurance athletes shows they increase VO2Max, increase the body’s ability to adapt to high levels of physical stress, increase anaerobic threshold and reduce lactic acid.


    A study done by South Dakota State University showed OptygenHP reduces cortisol levels (the primary stress hormone) by 26%. Chronically elevated cortisol levels can prevent an athlete from recovering, increase the risks of overtraining and suppress the immune system. 


    A 2012 study done at Luther College showed endurance athletes who used OptygenHP increased time to lactate threshold by 42%. The purpose of this study was to determine the effects on highly trained distance runners of OptygenHP.

    Though changes in performance variables (VO2 max, hemoglobin, serum ferritin and salivary cortisol) were similar between groups, time to onset of lactate threshold was nearly 42% greater in E=experimental vs C=control group.


    Q: How is this new OptygenHP formula different than the current formula?

    A: This new formula contains the adaptogenic herb ashwagandha.  Research shows ashwaganda improves VO2max, modulates cortisol and increases work output.    We have substituted 150mg of Rhodiola with 150mg of ashwagandha. The new formula delivers 150mg Rhodiola, 150mg ashwagandha, 800mg cordyceps, 200mcg chromium, 50mg ActiGin and our proprietary ATPro matrix.

    Q:  How will this new & improved OptygenHP formula formula help me race better?

    A:  This new & improved formula will dramatically improve your training and recovery.  It’s designed to help you through your most intense training and racing. Research has shown the following endurance benefits:

    • Increases Endurance and Performance
    • Reduced Lactic Acid
    • Increases oxygen utilization
    • Increase in VO2 Max
    • Increase in Time to Exhaustion
    • Increase Anaerobic threshold
    • Improved exercise capacity
    • Increase Maximal Oxygen uptake
    • 30% – 50% increase in Oxygen Utilization
    • Increase ratio of ATP by 45% – 55%
    • Enhanced Endurance
    • Increase in ATP production 

    Q: How do I maximize the benefits of the new formula?

    A:  For best results, use the OptygenHP during all your intense training and racing. This will allow you to train at a higher level by improving the body’s ability to adapt to physical stress, increasing anaerobic threshold and reducing lactic acid. These improvements will help you race at a higher level. For best results, you should use the new & improved OptygenHP consistently for many months. If you start taking it a week before a race, benefits will be minimal. 

    Q: Should I take OptygenHP every day?

    A: Yes, it’s important to take OptygenHP daily, even on days you are not training or racing.  If you don’t take it every day, you will not experience the full potential.

    Q: How long will it take before I start noticing the benefits?

    A: You should start experiencing the benefits of OptygenHP formula approximately six (6) days after you start taking it.

    Q: When should I take OptygenHP?

    A: It is best to take the new & improved OptygenHP formula every day with a meal.

    Q: What is Beta-Alanine and how does it work?

    A: Beta-Alanine is an amino acid that interacts directly with the amino acid carnosine to buffer lactic acid. With intense training, you can increase your carnosine levels with a limiting factor: the body cannot produce enough Beta-Alanine to allow the body to continue to increase carnosine levels. Clinical studies show that supplementing with Beta-Alanine allows the body to produce significantly higher carnosine levels. The result is a highly effective mechanism for the metabolism of lactate, which in-turn improves endurance capacity.

    Q: What are the benefits of taking Beta-Alanine?

    A: Cutting edge human clinical studies show Beta-Alanine supplementation:

    • Significantly improves muscular endurance.
    • Improves exercise capacity
    • Increases Total Work Done by 13%
    • Boosts strength

    • Increases endurance capacity
    • Enhances Ventilatory Threshold
    • Delays onset of neuromuscular fatigue

    Q:  Is the new OptygenHP formula legal?

    A: Absolutely.  First Endurance has taken additional measures to ensure that our products are safe, legal and stimulant free.  First Endurance supplements are legal to use in any sporting event governed by the World Anti-Doping Association (WADA), the US anti-doping association (USADA) and by the UCI (Union Cycliste International), US Cycling, International Cycling, US Triathlon and International Triathlon.  

    Some commonalties among these governing bodies include banned substances which fall into one or more of the following categories as listed in Section I A-E of the UCI Prohibited Classes of substance and Prohibited Methods document.  A) Stimulants B) Narcotics C) Anabolic agents D) Diuretics and E) Peptide hormones, mimetics and analogues. This document goes on to list banned substances within each of these classes. Regulations also ban ‘Compounds chemically or pharmacologically related to the products mentioned’.  

    OptygenHP contains NO ingredients, which are explicitly listed under the banned substance list, nor are any of the ingredients related chemically or pharmacologically.  First Endurance has also contacted the USADA and received verbal confirmation that our ingredients are not banned based on their regulations. Note: USADA, WADA and UCI do not offer any certification or written confirmation.  

    First Endurance manufactures its formulations to the highest GMP (Good Manufacturing Practice) standards available.  In addition we use a proprietary manufacturing method for added safety and assurance. Following the Supplement Facts panel you will notice we list ‘NO processing aids’ under Other Ingredients.   The only ingredients found in this formulation, are those listed in the Supplement Facts Panel.

    Part XIV Article 7 of the Anti-doping Examination Regulations contains the following warning: riders must refrain from using any substance, foodstuff or drink of which they do not know the composition.  It must be emphasized that the composition indicated on a product is not always complete. The product may contain prohibited substances not listed in the composition.

    Q: Will this new & improved OptygenHP formulation help me recover faster?

    A: Yes, it will help you recover.  Because this formula was developed to help you adapt during times of maximum stress, it also aids in recovery.

    Q: Should I ‘cycle’ on and off with Optygen/OptygenHP?

    A: Great question. Both these products work best when you are ‘stressed’, so use the product during stressful training. The cycling period should parallel your training program. In other words, you should be using Optygen/OptygenHP consistently through all hard training blocks/months and go off anytime you have a break or downtime. For some, this means being on the product through most if not all the racing season. For others it might mean cycling off for a week once every 4-6 weeks.



    Efficient Glucose Metabolism

    The OptygenHP formula utilizes chromium for its ability to break down fuel. Chromium is an essential trace mineral that aids in glucose metabolism, regulation of insulin levels, and maintenance of healthy blood levels of cholesterol and other lipids. Chromium forms part of a compound in the body known as glucose tolerance factor (GTF), which is involved in regulating the actions of insulin in maintaining blood sugar levels and, possibly, in helping to control appetite. It is critical that any drink, bar or pre-race meal consumed prior to a race or exercise gets broken down efficiently in order to maximize fuel delivery.  Insulin spikes or lack of insulin response can cause the nutrients to either be rushed into the bloodstream too quickly or not quickly enough.  Chromium regulates this nutrient breakdown so equal and sustained nutrients are delivered to the working muscles. The most widely available sources are chromium salts such as chromium polynicotinate and chromium picolinate. OptygenHP uses chromium chelate, a unique form of chromium patented for its superior absorption and bioavailability properties.

    Efficient Oxygen Transfer

    OptygenHP contains adaptogenic herbs to improve oxygen efficiency.  This next-generation formula has been upgraded with Ashwagandha to enhance VO2 Max more than ever before.

    Originally, these adaptogenic herbs were gathered by Tibetan Sherpas for use in their tea. The Sherpas used these herbs to give them energy to climb Everest, which they did without the use of supplemental oxygen. One of the adaptogenic applications of Rhodiola that has received considerable research attention recently is in adaptation to high altitude – a preventive treatment for hypoxia, or mountain sickness. In June 2002, Dr. Rulin Xiu was awarded a patent for her work showing Rhodiola’s ability to oxygenate blood. Clinical studies on Cordyceps have proven its ability to increase endurance through more efficient enzyme activity, mobilization of free fatty acids and beta-oxidation. In a 1998 study, Dr. Edmond Burke observed that Cordyceps has the ability to improve lactate energy metabolism within the cell. All these mechanisms clearly show how these two adaptogenic herbs improve the efficiency of oxygen transfer in the cell leading to improvements in oxygen uptake and VO2max.

    Lactate Synthesis

    OptygenHP utilizes Beta-alanine to efficiently synthesize lactate to be re-used as fuel. Beta-alanine is a non-essential beta-amino acid. L-carnosine enters the digestive system and is hydrolyzed into histidine and beta-alanine, which is then synthesized back into carnosine by skeletal muscle. It is with intense training that athletes improve their muscle carnosine content by up to 87% (Harris, 2005). With intense training, carnosine levels can be increased, but with a limiting factor: the body cannot produce enough beta-alanine to allow the body to continue to increase carnosine levels. Clinical studies show that supplementing with beta-alanine allows the body to produce significantly higher carnosine levels. Through its effect on carnosine levels, beta-alanine synthesizes lactic acid to be re-used as fuel.  The result is a highly effective mechanism for the metabolism of lactate, which in turn improves endurance capacity allowing training and racing at a higher level.

    ATP Production

    OptygenHP increases efficient Adenosine Triphosphate (ATP) production. Clinical research has shown that endurance athletes diminish their ATP stores in exhaustive exercise, which can lead to a reduction in aerobic metabolism and endurance. OptygenHP’s proprietary ATPro™ matrix of five key nutrients is designed to ensure ATP production.  Since ATP is the final step in aerobic energy production, it is critical that the nutrients feeding the ATP cycle are readily available. Calcium pyruvate, sodium phosphate, potassium phosphate, adenosine and d-ribose all play critical roles in glycolysis and the citric acid cycle, leading to efficient ATP production. An endurance athlete’s VO2max is directly proportional to the body’s ability to efficiently produce ATP.



    First Endurance offers everything an endurance athlete needs to maximize endurance and performance.  We designed it to work as a complete endurance system. Each product has a specific purpose and complements the others.

    With First Endurance, there’s no more guesswork.